JORR

The Journal of Orthopedics Research and Rehabilitation welcomes scholarly papers in orthopaedic surgery, physical therapy and rehabilitation, physiotherapy, neurology and clinic anesthesiology and reanimation.

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Gene therapy: molecular foundations, therapeutic strategies, and emerging applications in dentistry and orthodontics
Gene therapy represents a revolutionary biomedical approach aimed at treating diseases at their genetic root by modifying or regulating gene expression. Advances in molecular biology have enabled the development of targeted gene delivery systems capable of correcting inherited disorders, modulating pathological gene activity, and enhancing tissue regeneration. This review provides a comprehensive overview of the fundamental principles of gene therapy, including cellular and genetic foundations, types of gene therapy, delivery strategies, vectors, and mechanisms of action. Special emphasis is placed on emerging applications in dentistry and orthodontics, such as management of orofacial pain, head and neck carcinomas, bone regeneration, salivary gland dysfunction, root resorption, tooth regeneration, cleft lip and palate, and biologically guided orthodontic tooth movement. The role of gene therapy in precision modulation of bone remodelling via the RANK–RANKL–OPG pathway is also highlighted. Despite promising clinical and experimental outcomes, challenges related to delivery efficiency, immune responses, safety, cost, and ethical concerns remain. Gene therapy, combined with tissue engineering and personalized medicine, holds immense potential to transform future dental and orthodontic practice.


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Volume 4, Issue 3, 2026
Page : 78-82
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