JORR

The Journal of Orthopedics Research and Rehabilitation welcomes scholarly papers in orthopaedic surgery, physical therapy and rehabilitation, physiotherapy, neurology and clinic anesthesiology and reanimation.

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Original Article
Differential diagnosis and management of cartilage-derived tumors in the upper extremity: a focus on osteochondroma and bizarre parosteal osteochondromatous proliferation
Aims: Among cartilage-derived tumors in the hand, osteochondroma is the second most common benign lesion after enchondromas. Bizarre parosteal osteochondromatous proliferation (BPOP) is particularly rare in the hand and may be confused with malignant processes. This study presents the outcomes of surgically treated exophytic benign bone masses. The aim is to differentiate between these two lesions, which are very similar clinically, radiologically, and histopathologically.
Methods: Nine patients who underwent surgery due to a mass in the hand, with a histopathological diagnosis of osteochondroma-BPOP, were included in the study. Surgeries were performed under axillary anesthesia by a single surgeon certified in hand surgery. The demographic data of the patients, characteristics of the mass, and associated clinical findings were recorded. Functional outcomes at the final outpatient follow-up after mass excision were assessed using VAS and q-DASH scores. Surgical complications and recurrence were also investigated.
Results: The average age of the patients participating in the study was 40 years (range: 14-64 years). The average follow-up period after surgery was 30 months (range: 8-120 months). A total of 9 patients underwent surgery due to a palpable mass, with histopathologically confirmed diagnoses reporting 6 cases of solitary osteochondroma and 3 cases of BPOP. During the follow-up period, 1 patient developed a recurrent mass, and this patient with a diagnosis of BPOP underwent reoperation. Clinically, all patients experienced a resolution of preoperative complaints, and significant improvements were observed in clinical scores.
Conclusion: Symptomatic classical osteochondroma and BPOP lesions cause concern for patients. Successful outcomes can be achieved through surgical excision. However, after excluding malignancy, it is important to differentiate between these lesions. It will be beneficial to be aware of the high recurrence rates in cases considered similar to osteochondroma excision, such as BPOP lesions, and to maintain a diligent follow-up.


1. Bayar E, Cengiz T, Şimşek ŞA, Coşkun HS, Dabak N. Hand tumors: retrospective evaluation of 223 patients in a single center. Hand Microsurg. 2025;14(1):14-22. doi:10.5455/handmicrosurg.194643
2. Hacisalihoglu P, Ozcelik IB. Epidemiological and histopathological analysis of soft tissue tumors of the hand-9 years of experience from a single center. Hand Microsurg. 2019;8(1):1-8. doi:10.5455/handmicrosurg.16148
3. Mysore M, Murthy S, Nekkanti S, Nanjesh P. A rare case of recurrent enchondroma of the thumb involving the first metacarpophalangeal joint- an unusual disease pattern. Hand Microsurg. 2018;7(3):160-165. doi:10.5455/handmicrosurg.282349
4. Albanese KM, Lynch CP, Eswaran SP, Damron TA. Benign bone tumors of the hand: beyond enchondromas. J Am Acad Orthop Surg. 2024;33(17):e1000-e1016. doi:10.5435/JAAOS-D-23-01020
5. Teodoreanu RN, Grosu-Bularda A, Lita FF, et al. Benign cartilaginous tumors of the hand, a five-year retrospective study. Rom J Morphol Embryol. 2022;63(4):625-632. doi:10.47162/RJME.63.4.04
6. Khodnapur G, Patil A V, G S, M K B. Occurrence of osteochondroma at unusual location (metacarpal): a rare case report. J Orthop Case Reports. 2022;12(1):6-9. doi:10.13107/JOCR.2022.V12.I01.2592
7. Nora FE, Dahlin DC, Beabout JW. Bizarre parosteal osteochondromatous proliferations of the hands and feet. Am J Surg Pathol. 1983;7(3):245-250. doi:10.1097/00000478-198304000-00003
8. Smith NC, Ellis AM, McCarthy S, McNaught P. Bizarre parosteal osteochondromatous proliferation: a review of seven cases. Aust N Z J Surg. 1996;66(10):694-697. doi:10.1111/J.1445-2197.1996.TB00720.X
9. Larbi A, Viala P, Omoumi P, et al. Cartilaginous tumours and calcified lesions of the hand: a pictorial review. Diagn Interv Imaging. 2013;94(4):395-409. doi:10.1016/j.diii.2013.01.012
10. Herget GW, Kontny U, Saueressig U, et al. osteochondrom und multiple osteochondrome: empfehlungen zur diagnostik und vorsorge unter besonderer berücksichtigung des auftretens sekundärer chondrosarkome. Radiologe. 2013;53(12):1125-1135. doi:10.1007/S00117-013-2571-9
11. Tepelenis K, Papathanakos G, Kitsouli A, et al. Osteochondromas: an updated review of epidemiology, pathogenesis, clinical presentation, radiological features and treatment options. In Vivo (Brooklyn). 2021;35(2):681-691. doi:10.21873/INVIVO.12308
12. Berber O, Dawson-Bowling S, Jalgaonkar A, et al. Bizarre parosteal osteochondromatous proliferation of bone: clinical management of a series of 22 cases. J Bone Jt Surg Ser B. 2011;93B(8):1118-1121. doi:10. 1302/0301-620X.93B8.26349
13. Rueda-de-Eusebio A, Gomez-Pena S, Moreno-Casado MJ, Marquina G, Arrazola J, Crespo-Rodríguez AM. Hereditary multiple exostoses: an educational review. Insights Imaging. 2025;16:1. doi:10.1186/S13244-025-01899-6
14. Matsui Y, Funakoshi T, Kobayashi H, Mitsuhashi T, Kamishima T, Iwasaki N. Bizarre parosteal osteochondromatous proliferation (Nora’s lesion) affecting the distal end of the ulna: a case report. BMC Musculoskelet Disord. 2016;17:1. doi:10.1186/S12891-016-0981-3
15. Gruber G, Giessauf C, Leithner A, et al. Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature.Can J Surg. 2008;51(6):486-489.
16. Washington E, Menendez L, Fedenko A, Tomasian A. Bizarre parosteal osteochondromatous proliferation: Rare case affecting distal ulna and review of literature. Clin Imaging. 2021;69:233-237. doi:10.1016/j.clinimag.2020.08.019
17. Tiwari V, Dwidmuthe S, Bhikshavarthi Math SA, Roy M, Chaudhari SR. Bizarre parosteal osteochondromatous proliferation (Nora’s lesion) affecting carpal bones of the hand in a middle-aged female: a case report. Cureus. 2024;16:3. doi:10.7759/Cureus.56772
18. Lin J, Wang W, Chen G, Chen C. Nan Fang Yi Ke Da Xue Xue Bao. 2013; 33(9):1390-1393.
19. Zhao T, Zhao H. Computed tomographic image processing and reconstruction in the diagnosis of rare osteochondroma. Comput Math Methods Med. 2021;2021. doi:10.1155/2021/2827556
20. Chamberlain AM, Anderson KL, Hoch B, Trumble TE, Weisstein JS. Benign parosteal osteochondromatous proliferation of the hand originally diagnosed as osteochondroma: a report of two cases and review. Hand. 2010;5(1):106-110. doi:10.1007/S11552-009-9217-4
21. Endo M, Hasegawa T, Tashiro T, et al. Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation. Virchows Arch. 2005;447(1):99-102. doi:10.1007/S00428-005-1266-7
22. Nishio J, Shinohara Y, Nakayama S, Koga M, Aoki M, Koga T. Bizarre parosteal osteochondromatous proliferation revisited. In Vivo. 2025; 39(4):1799-1809. doi:10.21873/Invivo.13981
23. Garcia SA, Ng VY, Iwamoto M, Enomoto-Iwamoto M. Osteochondroma pathogenesis: mouse models and mechanistic insights into interactions with retinoid signaling. Am J Pathol. 2021;191(12):2042-2051. doi: 10. 1016/j.ajpath.2021.08.003
24. Badders JD, Carmichael KD. Spontaneous resolution of an osteochondroma. Cureus. 2023;15:4. doi:10.7759/Cureus.37565
25. Hill CE, Boyce L, Van Der Ploeg ID. Spontaneous resolution of a solitary osteochondroma of the distal femur: a case report and review of the literature. J Pediatr Orthop Part B. 2014;23(1):73-75. doi:10.1097/BPB.0000000000000010
26. Altay M, Bayrakci K, Yildiz Y, Erekul S, Saglik Y. Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients. J Orthop Sci. 2007;12(5):415-423. doi:10.1007/s00776-007-1152-z
27. Abramovici L, Steiner GC. Bizarre parosteal osteochondromatous proliferation (Nora’s lesion): a retrospective study of 12 cases, 2 arising in long bones. Hum Pathol. 2002;33(12):1205-1210. doi:10.1053/hupa. 2002.130103
28. Paula SHVC de, Cascaes P de SL, Peralta-Mamani M, Soares AB, Junqueira JL, Soares MQS. Bizarre parosteal osteochondromatous proliferation in the jaws: a systematic review. Oral Maxillofac Surg. 2025;29(1). doi:10.1007/S10006-025-01352-4
29. Khare GN. An analysis of indications for surgical excision and complications in 116 consecutive cases of osteochondroma. Musculoskelet Surg. 2011;95(2):121-125. doi:10.1007/S12306-011-0143-6
Volume 4, Issue 2, 2026
Page : 28-33
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